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Content :
Aplastic anemia (AA) is a rare, non-cancerous, and serious condition in which the stem cells in the bone marrow, responsible for producing all types of blood cells, are unable to produce a sufficient number of normal blood cells.
Aplastic anemia can result from either inherited or acquired factors that contribute to the damage of the stem cells in your bone marrow. Consequently, the bone marrow produces fewer red blood cells, white blood cells, and platelets, leading to the condition known as pancytopenia.
Patients with this condition can present across a spectrum, which ranges from being asymptomatic with incidental findings on peripheral blood testing to experiencing life-threatening neutropenic infections or bleeding.
A few decades ago, aplastic anemia was often fatal, but now it can be treated effectively with stem-cell transplantation or immunosuppressive drugs.
People of all ages can develop aplastic anemia. However, it's most common in adolescents (15 to 20 years of age) , and the elderly (over 60 years old). The incidence of AA is similar in men and women
Aplastic anemia is primarily classified into inherited, which is often linked to genetic factors, and acquired. The acquired pattern can be further classified into three major types based on disease severity and accompanying clinical signs, as follows:
MAA, or Non-severe aplastic anemia (NSAA), is characterized by chronically low blood counts without clinical evidence of progression. Patients may have lower blood cell counts than normal, but not as low as in severe aplastic anemia. Symptoms are generally rare or absent in this type of aplastic anemia.
characterized by chronic moderately depressed blood counts without clinical evidence of progression.In this type, symptoms intensify and the patient's condition becomes somewhat serious. The most important indicators of entry into this type are a hypocellular bone marrow and any two of the following criteria:
Very severe aplastic anemia, is the most dangerous type of this disease. Laboratory test values are similar to those of the previous type, but the differentiating factor is the extremely low count of neutrophils:
Aplastic anemia is caused by damage to stem cells, and various factors may be involved in this damage.
In the early stages of aplastic anemia, patients may not initially notice any symptoms or signs, but gradually experience fatigue and weakness, often accompanied by other symptoms that help confirm the diagnosis. Some of the most significant signs:
The supervising physician diagnoses aplastic anemia by considering the clinical signs mentioned above, along with conducting a series of tests and examinations, which include
The diagnosis of aplastic anemia should be suspected in any patient presenting with pancytopenia. The results that can orient the doctor to the diagnosis of aplastic anemia include:
There are several treatment options for aplastic anemia that depend on the patient's health status and the severity of their disease. However, the main treatment methods can be summarized into 3 types, which are:
Aplastic anemia is a rare and serious condition that can result from various factors, including autoimmune disorders, toxins, medications, and viral infections. Diagnosing it often involves blood tests like the complete blood count (CBC)
Early diagnosis and appropriate treatment can significantly improve outcomes for aplastic anemia patients.
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