Vitamin B12 Supplements

Vitamin B12 deficiency is a common condition, prompting many individuals to inquire about the types of Vitamin B12 supplements to address this deficiency. This a crucial role in DNA formation and the production of normal red blood cells. To prevent severe health issues, it is essential to ensure an adequate daily intake.


◉ Introduction

Vitamin B12 is crucial for our nervous system, DNA, and red blood cell production, supporting overall health. Although it's naturally found in animal products, some people may not get enough from their diet alone. In these cases, B12 supplements are valuable.

This article helps you understand different types of B12 supplements—cyanocobalamin, methylcobalamin, hydroxocobalamin, adenosylcobalamin, and combinations. Knowing the differences will help you make informed choices to meet your health goals.


◉ The Needed Dose of Vitamin B12

The recommended daily amount of vitamin B12 varies for adults, children, and women, as established by the Food and Nutrition Board (FNB) at the National Academies of Sciences, Engineering, and Medicine through their Recommended Dietary Allowance (RDA).

◉ The Various Methods of Administering Vitamin B12 Supplements

◉ What Are The Types of Vitamin B12 Supplements?

There are generally four types of vitamin B12 supplements available: Methylcobalamin, Adenosylcobalamin, Cyanocobalamin, and Hydroxocobalamin. Some of these supplements, such as Methylcobalamin and Adenosylcobalamin, are naturally occurring co-enzymes found in food.

On the other hand, Cyanocobalamin is a synthetic form of vitamin B12 that transforms into Methylcobalamin and Adenosylcobalamin within the body. This synthetic form is commonly found in supplements and fortified foods.

1- Cyanocobalamin

Cyanocobalamin is a synthetic form of vitamin B12 designed to elevate your blood's vitamin B12 levels. If you've been diagnosed with low vitamin B12, taking cyanocobalamin can alleviate symptoms such as fatigue, lack of energy, or shortness of breath.

This synthetic form is derived from a small amount of cyanide molecules, a component that, in trace amounts, contributes to the effectiveness of cyanocobalamin as a vitamin B12 supplement.

Cyanocobalamin B12 supplements are available over-the-counter at pharmacies, supermarkets, and health food stores in various forms, including tablets, capsules, mouth sprays, injections and drops.

These supplements are available in strengths ranging from 10 to 1,000 micrograms (μg). It is generally recommended to take the tablets on an empty stomach, which means waiting at least 2 hours after a meal or snack, and at least 30 minutes before your next meal.

2- Hydroxocobalamin

Hydroxocobalamin is a highly bioavailable form of vitamin B12 supplement, naturally produced by certain bacteria in the digestive tract during food digestion. Additionally, it can be synthesized in a laboratory setting.

This particular type of vitamin B12 supplement is often utilized for the treatment of severe vitamin B12 deficiencies. Hydroxocobalamin is exclusively available with a doctor's prescription and administered through intramuscular (IM) or intravenous (IV) injection.

3- Methylcobalamin

Methylcobalamin is the most readily available form of vitamin B12 in food, making it easily absorbed by body tissues. It is a naturally occurring co-enzyme found in animal-based foods such as meat, fish, milk, and eggs.

4- Adenosylcobalamin

Adenosylcobalamin is one of the types of vitamin B12 supplements that works in tandem with Methylcobalamin to fulfill the body's requirements for vitamin B12. This co-enzyme is naturally occurring, much like Methylcobalamin.

Furthermore, Adenosylcobalamin plays a crucial role in safeguarding the mitochondria, which are responsible for producing energy for the body's cells.

Considered an essential component of the myelin sheath, Adenosylcobalamin provides protection to nerve cells, facilitating rapid responses to various stimuli.

◉ When To Take Vitamin B12 Supplements?

The selection of various types of vitamin B12 supplements is based on the specific stage of your Vitamin B12 deficiency. It is advisable to take these supplements on an empty stomach, either 2 hours after a meal or 30 minutes before eating.

Cyanocobalamin is commonly available in tablet form, with concentrations ranging from 50 to 1,000 micrograms (μg). On the other hand, Hydroxocobalamin is obtainable by prescription in injectable form.

◉ Vitamin B12 Combination Supplements: What to Look For

Combination supplements that blend various forms of vitamin B12 offer a versatile approach to supplementation. Understanding what to look for when assessing these formulas ensures you make choices aligned with your individual health needs.

Assessing B12 Formulas with Multiple Types

Considerations for Personalized Supplementation

◉ Conclusion

In conclusion, Vitamin B12 supplements offer a diverse array of options, each with its unique benefits and considerations. Whether you choose cyanocobalamin for its cost-effectiveness, methylcobalamin for direct usability, or a combination formula for a comprehensive approach, understanding these distinctions is vital. As you embark on your supplementation journey, consider your health goals, individual tolerances, and consultation with healthcare professionals. Remember, the right choice is the one that aligns with your needs, ensuring a well-rounded approach to supporting your overall health and well-being.


Sources

  1. Office of Dietary Supplements - Vitamin B12. (n.d.). https://ods.od.nih.gov/factsheets/VitaminB12-Consumer/
  2. Office of Dietary Supplements - Vitamin B12. (n.d.). https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
  3. Website, N. (2023, July 14). Cyanocobalamin. nhs.uk. https://www.nhs.uk/medicines/cyanocobalamin/
  4. Royal United Hospital Bath NHS - Guidelines for the Investigation & Management of vitamin B12 deficiency
  5. Carol Rees Parrish, M.S., R.D., Series Editor. Revisiting Vitamin B12 Deficiency: A Clinician’s Guide For the 21st Century
  6. Gupta JK* and Qureshi Shaiba Sana. Potential Benefits of Methylcobalamin: A Review
  7. Injection de cyanocobalamine, USP 10 000 mcg | SteriMax Inc. (2018, June 6). SteriMax Inc. https://sterimaxinc.com/fr/products/injectables/cyanocobalamin/cyanocobalamin-10000-mcg/